منابع مشابه
Signal processing in cellular clocks.
Many biochemical events within a cell need to be timed properly to occur at specific times of day, after other events have happened within the cell or in response to environmental signals. The cellular biochemical feedback loops that time these events have already received much recent attention in the experimental and modeling communities. Here, we show how ideas from signal processing can be a...
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متن کاملCellular circadian clocks in mood disorders.
Bipolar disorder (BD) and major depressive disorder (MDD) are heritable neuropsychiatric disorders associated with disrupted circadian rhythms. The hypothesis that circadian clock dysfunction plays a causal role in these disorders has endured for decades but has been difficult to test and remains controversial. In the meantime, the discovery of clock genes and cellular clocks has revolutionized...
متن کاملCellular clocks and light effects on man
In principle, there are two types of time regulation in humans as well as in other species: Cyclic time when the same phenomena occur with regular intervals, and linear time, when alterations occur along a straight line. Examples of the former are circadian and seasonal variations, while the latter time functions include periods of gestation, infancy, growth and adulthood, followed by senescenc...
متن کاملThe Interdependence of Membrane Shape and Cellular Signal Processing
Cellular membranes are constantly reshaped by vesicular fission and fusion as well as by interactions with the dynamic cytoskeleton. Signaling activity at membranes depends on their geometric parameters, such as surface area and curvature; these affect local concentration and thereby regulate the potency of molecular reactions. A membrane's shape is thus inextricably tied to information process...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2011
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1004720108